what drugs can prevent breast cancer?
as the age increases, the risk of breast cancer will increase for women, just like heart disease or osteoporosis. Taking statins or aspirin can prevent cardiovascular diseases. Calcium supplements can prevent osteoporosis. Is there a similar medicine that can prevent breast cancer? Some drugs,
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aromatase inhibitors can prevent breast cancer by reducing estrogen release. Estrogen not only promotes the development of female sex signs, but also promotes the growth of some breast tumors, and our bodies rely on aromatase to make estrogen, and the inhibition of aromatase is like a tumour cauldron. Exemestane is the latest aromatase inhibitor. A 3 year clinical trial in the US showed that women who took exemestane reduced the risk of breast cancer by 65% compared to placebo. More studies are now being carried out to confirm whether the preventive effect of exemestane can continue,
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Among the
selective estrogen receptor modulators, tamoxifen is the most common preventive agent for breast cancer. It can reduce the risk of breast cancer in women by reducing the effects of estrogen on the body. A US study called breast cancer prevention clinical trial found that 5 years of tamoxifen (60 milligrams a day) reduced the risk of breast cancer in menopause women by 50%. The United States Food and Drug Administration (FDA) has approved tamoxifen for women with high risk of breast cancer to reduce the risk of breast cancer. Another selective estrogen receptor modulator,
columbia jacket, called raloxifene, is also approved by FDA for breast cancer prevention. In clinical trials, 25 mg of raloxifene daily for 5 years can reduce the risk of breast cancer in women by 35%.
How does
judge who can benefit from it?
even though tamoxifen and raloxifene have been approved by FDA for breast cancer prevention, the side effects of the drugs are still worrying. Selective estrogen receptor modulators can play a role in reducing estrogen in some parts of the body, and can play the opposite role in other parts of the body. Tamoxifen, for example,
6pm designer clothes, is an estrogen receptor modulator in the breast tissue and is like an estrogen receptor agonist in the uterus and bones, which may increase the risk of developing cancer of the uterus or endometrium (although very low). However, for women who are at high risk of breast cancer, the hazards of drugs are far less than the benefits of preventive effects.
so, which women can benefit more from preventive medicine than harm? How to pick out high-risk women is a problem. The level of cholesterol and blood pressure can accurately predict the risk of heart disease, so cholesterol lowering drugs can effectively prevent heart disease. In the prevention of breast cancer, there is no such marker as cholesterol. BRCA1 and BRCA2 mutations do predict breast cancer risk, but >
